3122437-17-3
3122437-17-3
Chemical Structure
HDAC6-IN-87
- CAS No.: 3122437-17-3
- Formula:C27H23FN2O3
- Molecular Weight:442.48
InChIKey: VCOYZMMDKNTZTF-UHFFFAOYSA-N
SMILES: O=C(NO)C(C=C1)=CC=C1CN(CC2=CC=C(F)C=C2)C(CC3=CC(C=CC=C4)=C4C=C3)=O
Biological Activity: HDAC6-IN-87 is a selective HDAC6 inhibitor (IC50 = 4.29 nM). HDAC6-IN-87 weakly inhibits HDAC1 (IC50 = 749.59 nM), HDAC3 (IC50 = 813.09 nM), and HDAC10 (IC50 = 679.25 nM). HDAC6-IN-87 exhibits broad-spectrum antitumor activity, elevates α-tubulin acetylation levels without affecting histone H3 acetylation, and induces cell cycle arrest and apoptosis. HDAC6-IN-87 can be used for cancer-related research[1].
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HDAC6-IN-87 | HDAC6-IN-87 is a selective HDAC6 inhibitor (IC50 = 4.29 nM). HDAC6-IN-87 weakly inhibits HDAC1 (IC50 = 749.59 nM), HDAC3 (IC50 = 813.09 nM), and HDAC10 (IC50 = 679.25 nM). HDAC6-IN-87 exhibits broad-spectrum antitumor activity, elevates α-tubulin acetylation levels without affecting histone H3 acetylation, and induces cell cycle arrest and apoptosis. HDAC6-IN-87 can be used for cancer-related research. | |||||||||||||||||||||
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