3132777-83-1
3132777-83-1
Chemical Structure
BChE-IN-50
- CAS No.: 3132777-83-1
- Formula:C24H20F2N4O
- Molecular Weight:418.44
InChIKey: VROCSMSMFRPPHS-UHFFFAOYSA-N
SMILES: FC1=CC=CC=C1C(N/C(NC2=CC=C(F)C=C2)=N/CCC3=CNC4=C3C=CC=C4)=O
Biological Activity: BChE-IN-50 is an orally active human butyrylcholinesterase (hBChE) inhibitor with an IC50 of 0.28 μM and a Ki of 0.78 μM. As a ROS inhibitor, BChE-IN-50 protects nerve cells from toxic damage induced by hydrogen peroxide and Aβ1-42, and alleviates Aβ-induced cognitive impairment in mice. BChE-IN-50 can be used for the research of Alzheimer's disease[1].
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
BChE-IN-50 | BChE-IN-50 is an orally active human butyrylcholinesterase (hBChE) inhibitor with an IC50 of 0.28 μM and a Ki of 0.78 μM. As a ROS inhibitor, BChE-IN-50 protects nerve cells from toxic damage induced by hydrogen peroxide and Aβ1-42, and alleviates Aβ-induced cognitive impairment in mice. BChE-IN-50 can be used for the research of Alzheimer's disease. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
Keywords
