3133817-84-9
Chemical Structure
PARP1/PRMT5-IN-1
- CAS No.: 3133817-84-9
- Formula:C41H43FN8O4
- Molecular Weight:730.83
InChIKey: XSHGXCXBOGNVGX-PMERELPUSA-N
SMILES: O=C1NN=C(CC2=CC(C(N3CCC4(CC(NC5=NC=NC(C(NC[C@H](O)CN6CCC(C=CC=C7)=C7C6)=O)=C5)C4)CC3)=O)=C(F)C=C2)C8=CC=CC=C81
Biological Activity: PARP1/PRMT5-IN-1 is an inhibitor of PARP1 and PRMT5, with an IC50 of 0.60 nM against PARP1 and an IC50 of 4.67 nM against PRMT5. PARP1/PRMT5-IN-1 downregulates the homologous recombination (HR)-associated factors BRCA1, BRCA2, and RAD51, thereby suppressing homologous recombination function. PARP1/PRMT5-IN-1 induces the accumulation of DNA double-strand breaks. PARP1/PRMT5-IN-1 triggers apoptosis. PARP1/PRMT5-IN-1 is applicable for breast cancer research[1].
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PARP1/PRMT5-IN-1 | PARP1/PRMT5-IN-1 is an inhibitor of PARP1 and PRMT5, with an IC50 of 0.60 nM against PARP1 and an IC50 of 4.67 nM against PRMT5. PARP1/PRMT5-IN-1 downregulates the homologous recombination (HR)-associated factors BRCA1, BRCA2, and RAD51, thereby suppressing homologous recombination function. PARP1/PRMT5-IN-1 induces the accumulation of DNA double-strand breaks. PARP1/PRMT5-IN-1 triggers apoptosis. PARP1/PRMT5-IN-1 is applicable for breast cancer research. | |||||||||||||||||||||
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