3133883-15-2
Chemical Structure
PROTAC HDAC3 degrader-1
- CAS No.: 3133883-15-2
- Formula:C50H63N9O7S
- Molecular Weight:934.16
InChIKey: SJVKMGTYZIHISB-PFTYNQTKSA-N
SMILES: O=C([C@H]1N(C([C@@H](NC(CN2CCN(CCN(CC3=CC=C(C(NNCCC)=O)C=C3)C(C4=CC5=CC=CC=C5O4)=O)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC6=CC=C(C7=C(C)N=CS7)C=C6
Biological Activity: PROTAC HDAC3 degrader-1 is a selective PROTAC degrader targeting HDAC3 with a DC50 of 30.73 nM. PROTAC HDAC3 degrader-1 induces degradation of HDAC3 via the ubiquitin-proteasome system. PROTAC HDAC3 degrader-1 promotes apoptosis, induces DNA damage, and downregulates anti-apoptotic proteins Mcl-1 and Bcl-xL. PROTAC HDAC3 degrader-1 can be used for the research of acute myeloid leukemia[1].
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PROTAC HDAC3 degrader-1 | PROTAC HDAC3 degrader-1 is a selective PROTAC degrader targeting HDAC3 with a DC50 of 30.73 nM. PROTAC HDAC3 degrader-1 induces degradation of HDAC3 via the ubiquitin-proteasome system. PROTAC HDAC3 degrader-1 promotes apoptosis, induces DNA damage, and downregulates anti-apoptotic proteins Mcl-1 and Bcl-xL. PROTAC HDAC3 degrader-1 can be used for the research of acute myeloid leukemia. | |||||||||||||||||||||
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