3133892-41-5
Chemical Structure
NS06
- CAS No.: 3133892-41-5
- Formula:C20H22Cl2N4O6
- Molecular Weight:485.32
InChIKey: CRAMMOBUFOSIKK-UHFFFAOYSA-N
SMILES: ONC(CCCCNCCOC1=CC=C(Cl)C=C1C(NC2=CC=C([N+]([O-])=O)C=C2Cl)=O)=O
Biological Activity: NS06 is a dual-target inhibitor of STAT3 and HDAC, with a Kd of 5.82 μM for human STAT3, an IC50 of 129.1 nM for human HDAC1, an IC50 of 451.2 nM for human HDAC3, and an IC50 of 230.4 nM for human HDAC6. NS06 binds to STAT3 to inhibit its phosphorylation without altering the total STAT3 level; it inhibits the enzymatic activity of HDAC via coordination with Zn2+ at the catalytic center of HDAC1 and increases the acetylation level of histone H3. NS06 induces cell apoptosis, inhibits cancer cell migration and colony formation, and exhibits antiproliferative activity against solid tumor cells and 3D tumor spheroid models. NS06 is applicable to solid tumor-related research[1].
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NS06 | NS06 is a dual-target inhibitor of STAT3 and HDAC, with a Kd of 5.82 μM for human STAT3, an IC50 of 129.1 nM for human HDAC1, an IC50 of 451.2 nM for human HDAC3, and an IC50 of 230.4 nM for human HDAC6. NS06 binds to STAT3 to inhibit its phosphorylation without altering the total STAT3 level; it inhibits the enzymatic activity of HDAC via coordination with Zn2+ at the catalytic center of HDAC1 and increases the acetylation level of histone H3. NS06 induces cell apoptosis, inhibits cancer cell migration and colony formation, and exhibits antiproliferative activity against solid tumor cells and 3D tumor spheroid models. NS06 is applicable to solid tumor-related research. | |||||||||||||||||||||
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Keywords
