324054-99-1
324054-99-1
Chemical Structure
PD-L1-IN-11
- CAS No.: 324054-99-1
- Formula:C20H16N2O2
- Molecular Weight:316.35
InChIKey: ZHLHOYCEJNEVGW-UHFFFAOYSA-N
SMILES: O=C(C1=C(NC(C2=CC=C(C3=CC=CC=C3)C=C2)=O)C=CC=C1)N
Biological Activity: PD-L1-IN-11 is a PD-L1 inhibitor with human PD-L1 IC50 and KD of 27.82 μM and 49.50 μM, respectively. PD-L1-IN-11 directly binds to PD-L1 via a dimer-locking mechanism, occluding the PD-1 interaction surface to disrupt PD-1/PD-L1 interaction. PD-L1-IN-11 can be used for the research of melanoma, colon carcinoma[1][2].
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PD-L1-IN-11 | PD-L1-IN-11 is a PD-L1 inhibitor with human PD-L1 IC50 and KD of 27.82 μM and 49.50 μM, respectively. PD-L1-IN-11 directly binds to PD-L1 via a dimer-locking mechanism, occluding the PD-1 interaction surface to disrupt PD-1/PD-L1 interaction. PD-L1-IN-11 can be used for the research of melanoma, colon carcinoma. | |||||||||||||||||||||
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References
Keywords
