330819-85-7
330819-85-7
Chemical Structure
VU0029251
- CAS No.: 330819-85-7
- Formula:C10H11N3S2
- Molecular Weight:237.34
IUPAC Name: 2-(methylthio)-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-amine
InChIKey: WDDBZCKBRCTSOZ-UHFFFAOYSA-N
SMILES: NC1=C2C(SC3=C2CCC3)=NC(SC)=N1
Biological Activity: VU0029251 is a mGluR5 partial antagonist (Ki: 1.07 μM). VU0029251 inhibits glutamate induced calcium mobilization in HEK293 cell membranes expressing rat mGluR5 (IC50: 1.7 μM)[1].
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VU0029251 | VU0029251 is a mGluR5 partial antagonist (Ki: 1.07 μM). VU0029251 inhibits glutamate induced calcium mobilization in HEK293 cell membranes expressing rat mGluR5 (IC50: 1.7 μM). | |||||||||||||||||||||
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References
- [1]. Rodriguez, A.L., et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol. Pharmacol. 78(6), 1105-1123 (2010). [Content Brief]
Keywords
