333329-22-9
Chemical Structure
CD73-IN-19
- CAS No.: 333329-22-9
- Formula:C18H17N3O3S
- Molecular Weight:355.41
InChIKey: JRHYTFDGNPAZEZ-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(NC(C2=C(N)C3=C(C)C=C(C)N=C3S2)=O)C=C1)OC
Biological Activity: CD73-IN-19 (Compound 4ab) is a CD73 inhibitor (with a 44% inhibition rate of CD73 enzymatic activity at 100 μM). CD73-IN-19 (at 10 μM and 100 μM) can completely antagonize the blockade of T cell proliferation induced by TCR (T cell receptor) triggering (which is induced by CD73 activity), and it can also inhibit the hA2A receptor activity in HEK-293 cells (Ki is 3.31 μM). CD73-IN-19 holds promise for research in the field of immune diseases[1].
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CD73-IN-19 | CD73-IN-19 (Compound 4ab) is a CD73 inhibitor (with a 44% inhibition rate of CD73 enzymatic activity at 100 μM). CD73-IN-19 (at 10 μM and 100 μM) can completely antagonize the blockade of T cell proliferation induced by TCR (T cell receptor) triggering (which is induced by CD73 activity), and it can also inhibit the hA2A receptor activity in HEK-293 cells (Ki is 3.31 μM). CD73-IN-19 holds promise for research in the field of immune diseases. | |||||||||||||||||||||
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Keywords
