336784-82-8
Chemical Structure
Calebin A
- CAS No.: 336784-82-8
- Formula:C21H20O7
- Molecular Weight:384.38
InChIKey: UYEWRTKHKAVRDI-ASVGJQBISA-N
SMILES: COC(C=C1/C=C/C(OCC(/C=C/C2=CC(OC)=C(C=C2)O)=O)=O)=C(C=C1)O
Biological Activity: Calebin A is a PI3K/Akt/mTOR, MAPK, and NF-κB inhibitor with oral effectiveness. Calebin A can block the autophagy-repressive, inhibiting apoptosis. Calebin A has anti-tumor activity by epigenetic regulation. Calebin A suppresses adipogenesis, modulates thermogenesis, and enriches gut probiotics. Calebin A can be used in research on osteoarthritis, Alzheimer's disease, type 2 diabetes, malignant peripheral nerve sheath tumors, and colorectal cancer[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Calebin A | 98.0% | Calebin A is a PI3K/Akt/mTOR, MAPK, and NF-κB inhibitor with oral effectiveness. Calebin A can block the autophagy-repressive, inhibiting apoptosis. Calebin A has anti-tumor activity by epigenetic regulation. Calebin A suppresses adipogenesis, modulates thermogenesis, and enriches gut probiotics. Calebin A can be used in research on osteoarthritis, Alzheimer's disease, type 2 diabetes, malignant peripheral nerve sheath tumors, and colorectal cancer. | ||||||||||||||||||||
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- [1]. Oliveira AL, et al. Calebin A: Analytical Development for Pharmacokinetics Study, Elucidation of Pharmacological Activities and Content Analysis of Natural Health Products. J Pharm Pharm Sci. 2015;18(4):494-514. [Content Brief]
- [2]. Brockmueller A, et al. Calebin A modulates inflammatory and autophagy signals for the prevention and treatment of osteoarthritis. Front Immunol. 2024;15:1363947. Published 2024 Mar 4. [Content Brief]
- [3]. Brockmueller A, et al. Multifunctionality of Calebin A in inflammation, chronic diseases and cancer. Front Oncol. 2022;12:962066. Published 2022 Sep 16. [Content Brief]
- [4]. Lee MJ, et al. Calebin-A induced death of malignant peripheral nerve sheath tumor cells by activation of histone acetyltransferase. Phytomedicine. 2019;57:377-384. [Content Brief]
- [5]. Lee PS, et al. Calebin-A prevents HFD-induced obesity in mice by promoting thermogenesis and modulating gut microbiota. J Tradit Complement Med. 2022;13(2):119-127. Published 2022 Jan 5. [Content Brief]
Keywords
