342795-08-8
342795-08-8
Chemical Structure
Bragsin2
- CAS No.: 342795-08-8
- Formula:C11H6F3NO5
- Molecular Weight:289.16
IUPAC Name: 6-methoxy-5-nitro-2-(trifluoromethyl)-4H-chromen-4-one
InChIKey: WJUILHMXVGFAIS-UHFFFAOYSA-N
SMILES: O=C1C=C(C(F)(F)F)OC2=CC=C(OC)C([N+]([O-])=O)=C21
Biological Activity: Bragsin2 is a potent, selective and noncompetitive nucleotide exchange factor BRAG2 inhibitor, with an IC50 of 3 μM. Bragsin2 binds at the interface between the PH domain of BRAG2 and the lipid bilayer, leads BRAG2 unable to activate lipidated Arf GTPase. Bragsin2 affects breast cancer stem cells[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Bragsin2 | 99.85% | Bragsin2 is a potent, selective and noncompetitive nucleotide exchange factor BRAG2 inhibitor, with an IC50 of 3 μM. Bragsin2 binds at the interface between the PH domain of BRAG2 and the lipid bilayer, leads BRAG2 unable to activate lipidated Arf GTPase. Bragsin2 affects breast cancer stem cells. | ||||||||||||||||||||
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Bragsin2 (Standard) | ≥98% | Bragsin2 (Standard) is the analytical standard of Bragsin2 (HY-111550). This product is intended for research and analytical applications. Bragsin2 is a potent, selective and noncompetitive nucleotide exchange factor BRAG2 inhibitor, with an IC50 of 3 μM. Bragsin2 binds at the interface between the PH domain of BRAG2 and the lipid bilayer, leads BRAG2 unable to activate lipidated Arf GTPase. Bragsin2 affects breast cancer stem cells. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.81
HY-111549Bragsin1 -
Similarity Score 0.63
HY-115747Namoline -
Similarity Score 0.57
HY-W0277737-Methoxy-4-(trifluoromethyl)coumarin -
Similarity Score 0.56
HY-119176Oxyfluorfen -
Similarity Score 0.56
HY-208883'-Methoxy-4'-nitroflavone -
Similarity Score 0.55
HY-D00917-Ethoxy-4-trifluoromethylcoumarin -
Similarity Score 0.55
HY-W415273Caspase-3-IN-2 -
Similarity Score 0.55
HY-N66577-Hydroxy-4-methyl-8-nitrocoumarin -
Similarity Score 0.55
HY-W874850RFluorodifen (Standard) -
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