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Bragsin2 

Cat. No.: HY-111550
Handling Instructions

Bragsin2 is a potent, selective and noncompetitive nucleotide exchange factor BRAG2 inhibitor, with an IC50 of 3 μM. Bragsin2 binds at the interface between the PH domain of BRAG2 and the lipid bilayer, leads BRAG2 unable to activate lipidated Arf GTPase. Bragsin2 affects breast cancer stem cells.

For research use only. We do not sell to patients.

Bragsin2 Chemical Structure

Bragsin2 Chemical Structure

CAS No. : 342795-08-8

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Description

Bragsin2 is a potent, selective and noncompetitive nucleotide exchange factor BRAG2 inhibitor, with an IC50 of 3 μM. Bragsin2 binds at the interface between the PH domain of BRAG2 and the lipid bilayer, leads BRAG2 unable to activate lipidated Arf GTPase. Bragsin2 affects breast cancer stem cells[1].

IC50 & Target

IC50: 3 μM (BRAG2)[1]

In Vitro

Bragsin2 (50 μM) inhibits Arf GTPase activation in HeLa cells[1].
Bragsin2 (50 μM) inhibits the growth of SUM149 and S68, with no effect on SUM159, which lacks adhesion molecules such as integrins and cadherins[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

289.16

Formula

C₁₁H₆F₃NO₅

CAS No.

342795-08-8

SMILES

O=C1C=C(C(F)(F)F)OC2=CC=C(OC)C([N+]([O-])=O)=C21

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Room temperature in continental US; may vary elsewhere

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Bragsin2
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HY-111550
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Bragsin2

Cat. No.: HY-111550