351071-90-4
351071-90-4
Chemical Structure
TGX-155
Synonym(s): AZ12649385
- CAS No.: 351071-90-4
- Formula:C20H19FN2O3
- Molecular Weight:354.37
IUPAC Name: 8-(4-fluoro-2-methylphenoxy)-2-morpholinoquinolin-4(1H)-one
InChIKey: FZTZVNFKDPBYKA-UHFFFAOYSA-N
SMILES: O=C1C2=CC=CC(OC3=C(C=C(F)C=C3)C)=C2NC(N4CCOCC4)=C1
Biological Activity: TGX-155 (AZ12649385) is a selective inhibitor of PI3Kβ. TGX-155 has potential applications in antithrombotic therapy[1][2][3].
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TGX-155 | TGX-155 (AZ12649385) is a selective inhibitor of PI3Kβ. TGX-155 has potential applications in antithrombotic therapy. | |||||||||||||||||||||
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References
- [1]. Verheijen J C, et al. Phosphatidylinositol 3-kinase (PI3K) inhibitors as anticancer drugs[J]. Drugs Future, 2007, 32(6): 537-547.
- [2]. Nylander S, et al. Human target validation of phosphoinositide 3-kinase (PI3K)β: effects on platelets and insulin sensitivity, using AZD6482 a novel PI3Kβ inhibitor. J Thromb Haemost. 2012 Oct;10(10):2127-36. [Content Brief]
- [3]. Sturgeon SA, et al. Adaptation of the Folts and electrolytic methods of arterial thrombosis for the study of anti-thrombotic molecules in small animals. J Pharmacol Toxicol Methods. 2006 Jan-Feb;53(1):20-9. [Content Brief]
