353258-25-0
353258-25-0
Chemical Structure
X15695
- CAS No.: 353258-25-0
- Formula:C14H7ClF4N2
- Molecular Weight:314.67
SMILES: FC(C1=CN2C(C(Cl)=C1)=NC(C3=CC=C(F)C=C3)=C2)(F)F
Biological Activity: X15695 is selective and orally active estrogen receptor (ERα) degrader. X15695 is an aryl hydrocarbon receptor (AHR) ligand. X15695 enables AHR to form a complex with the ERα, promoting its proteasomal degradation. X15695 inhibits the breast cancer cells proliferation, promotes cell cycle block and induces apoptosis. X15695 can be used for the study of breast cancer[1][2].
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X15695 | 98.45% | X15695 is selective and orally active estrogen receptor (ERα) degrader. X15695 is an aryl hydrocarbon receptor (AHR) ligand. X15695 enables AHR to form a complex with the ERα, promoting its proteasomal degradation. X15695 inhibits the breast cancer cells proliferation, promotes cell cycle block and induces apoptosis. X15695 can be used for the study of breast cancer. | ||||||||||||||||||||
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References
- [1]. Katrin Koellisch, et al. Distinct 2-phenyl-imidazo[1, 2α] pyridine derivatives drive ER degradation and selectively impair proliferation of ER breast cancer cells via the aryl hydrocarbon receptor+. 2025 Aug 1
- [2]. Pan M, et al. Identification of an Imidazopyridine-based Compound as an Oral Selective Estrogen Receptor Degrader for Breast Cancer Therapy. Cancer Res Commun. 2023 Jul 27;3(7):1378-1396. [Content Brief]
Keywords
