35531-88-5
Chemical Structure
Carindacillin
Synonym(s): Indanyl carbenicillin; CP-15464-2 free base
- CAS No.: 35531-88-5
- Formula:C26H26N2O6S
- Molecular Weight:494.56
InChIKey: JIRBAUWICKGBFE-MNRDOXJOSA-N
SMILES: O=C(OC1=CC=C(CCC2)C2=C1)C(C3=CC=CC=C3)C(N[C@H]4[C@]5([H])N(C4=O)[C@H](C(C)(S5)C)C(O)=O)=O
Biological Activity: Carindacillin (Indanyl carbenicillin; CP-15464-2 free base) is an orally active prodrug of Carbenicillin (HY-B0525). Carindacillin undergoes intestinal uptake via a proton gradient-driven carrier-mediated pathway and is rapidly hydrolyzed in vivo to release the bioactive Carbenicillin, which interferes with cell wall synthesis by inhibiting bacterial penicillin-binding proteins. Carindacillin can be used in research related to bacterial infections[1][2].
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Carindacillin | Carindacillin (Indanyl carbenicillin; CP-15464-2 free base) is an orally active prodrug of Carbenicillin (HY-B0525). Carindacillin undergoes intestinal uptake via a proton gradient-driven carrier-mediated pathway and is rapidly hydrolyzed in vivo to release the bioactive Carbenicillin, which interferes with cell wall synthesis by inhibiting bacterial penicillin-binding proteins. Carindacillin can be used in research related to bacterial infections. | |||||||||||||||||||||
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References
- [1]. Li YH, et al. Role of the monocarboxylic acid transport system in the intestinal absorption of an orally active beta-lactam prodrug: carindacillin as a model. International journal of pharmaceutics. 1999 Nov 30;191(2):151-9.
- [2]. Michiels HG, et al. The treatment of chronic pyelonephritis with carindacillin. Current medical research and opinion. 1978;5(5):394-400.
