357330-77-9
Chemical Structure
JTC-017
- CAS 番号: 357330-77-9
- Formula:C20H25Cl2N3O5S
- Molecular Weight:490.40
IUPAC Name: 3,5-dichloro-N-(5-(N,N-diethylsulfamoyl)-3-(dimethylamino)-2-methoxyphenyl)-4-hydroxybenzamide
InChIKey: DFHUSLVYQHBBEV-UHFFFAOYSA-N
SMILES: O=C(C1=CC(Cl)=C(C(Cl)=C1)O)NC2=CC(S(=O)(N(CC)CC)=O)=CC(N(C)C)=C2OC
Biological Activity: JTC-017, a specific corticotropin-releasing hormone receptor 1 antagonist, attenuates hippocampal noradrenaline release, visceral perception, adrenocorticotropic hormone release, and anxiety after acute colorectal distention in rats. JTC-017 blocks stress-induced changes in colonic motility after chronic colorectal distention in rats[1].
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JTC-017 | JTC-017, a specific corticotropin-releasing hormone receptor 1 antagonist, attenuates hippocampal noradrenaline release, visceral perception, adrenocorticotropic hormone release, and anxiety after acute colorectal distention in rats. JTC-017 blocks stress-induced changes in colonic motility after chronic colorectal distention in rats. | |||||||||||||||||||||
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