36001-47-5
Chemical Structure
Vescalagin
- CAS No.: 36001-47-5
- Formula:C41H26O26
- Molecular Weight:934.63
IUPAC Name: 2,3,4,5,6,7,15,16,17,19,20,21,23,24,25,36-hexadecahydroxy-11a,29,30,30a-tetrahydro-11H,13H,27H-30,18,22-(epoxyethane[1,2,2]triyl)-26,29-methanodibenzo[h,o]dibenzo[7,8:9,10][1,5]dioxacycloundecino[3,2-b][1,6]dioxacycloheptadecine-9,13,27,32,34-pentaone
InChIKey: SHLHLINHDWPIMJ-NZSFLSJISA-N
SMILES: OC1=C(O)C(O)=C(C2=C3C=C(O)C(O)=C2O)C=C1C(OC[C@](OC(C4=C(C5=C6C(C7=C(C(O[C@@]8([H])[C@@H]9O)=O)C9=C(O)C(O)=C7O)=C(O)C(O)=C5O)C(O)=C(O)C(O)=C4)=O)([H])[C@@]([C@@H]8OC6=O)([H])OC3=O)=O
Biological Activity: Vescalagin is a hexahydroxyphenol. Vescalagin is isolable from Camu-camu (Myrciaria dubia) and immature wax apple fruits. Vescalagin exhibits inhibitory activity against a variety of enzymes, with a Ki value of 5.87 nM against AChE, 3.89 nM against BChE, 11.75 nM against hCA I, 16.23 nM against hCA II, and 16.08 nM against α-glucosidase. Vescalagin inhibits hCA I, hCA II and α-glucosidase in a non-competitive manner. Vescalagin downregulates JNK/p38 MAPK to protect pancreatic β-cells and improve insulin secretion in methylglyoxal-treated rats. Vescalagin reduces hyperglycemia and hypertriglyceridemia in rats fed a high-fructose diet. Vescalagin possesses anti-inflammatory and antioxidant properties[1].
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Vescalagin | Vescalagin is a hexahydroxyphenol. Vescalagin is isolable from Camu-camu (Myrciaria dubia) and immature wax apple fruits. Vescalagin exhibits inhibitory activity against a variety of enzymes, with a Ki value of 5.87 nM against AChE, 3.89 nM against BChE, 11.75 nM against hCA I, 16.23 nM against hCA II, and 16.08 nM against α-glucosidase. Vescalagin inhibits hCA I, hCA II and α-glucosidase in a non-competitive manner. Vescalagin downregulates JNK/p38 MAPK to protect pancreatic β-cells and improve insulin secretion in methylglyoxal-treated rats. Vescalagin reduces hyperglycemia and hypertriglyceridemia in rats fed a high-fructose diet. Vescalagin possesses anti-inflammatory and antioxidant properties. | |||||||||||||||||||||
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Keywords
