396726-03-7
Chemical Structure
HMBPP lithium
Synonym(s): (E)-4-Hydroxy-3-methyl-but-2-enyl diphosphate lithium
- CAS No.: 396726-03-7
- Formula:C5H9Li3O8P2
- Molecular Weight:279.89
IUPAC Name: lithium (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate
InChIKey: OXTOLNWLFPIFRM-JZWSQSCTSA-K
SMILES: O=P(OP(O[Li])(O[Li])=O)(O[Li])OC/C=C(C)/CO
Biological Activity: HMBPP lithium is an intermediate in isoprenoid biosynthesis that can be produced by bacteria and protozoa that use the non-mevalonate pathway for isoprenoid biosynthesis. HMBPP lithium is a ligand of the internal domain of BTN3A1 and is an activator for human Vγ9/Vδ2 T cells. HMBPP lithium exhibits phagostimulant property in mosquitos[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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HMBPP lithium | 98.0% | HMBPP lithium is an intermediate in isoprenoid biosynthesis that can be produced by bacteria and protozoa that use the non-mevalonate pathway for isoprenoid biosynthesis. HMBPP lithium is a ligand of the internal domain of BTN3A1 and is an activator for human Vγ9/Vδ2 T cells. HMBPP lithium exhibits phagostimulant property in mosquitos. | ||||||||||||||||||||
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References
- [1]. Hintz M, et al., Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gammadelta T cells in Escherichia coli. FEBS Lett. 2001 Dec 7;509(2):317-22. [Content Brief]
- [2]. Stromsky VE, et al., Plasmodium metabolite HMBPP stimulates feeding of main mosquito vectors on blood and artificial toxic sources. Commun Biol. 2021 Oct 7;4(1):1161. [Content Brief]
- [3]. Rosso DA, et al. Glioblastoma cells potentiate the induction of the Th1-like profile in phosphoantigen-stimulated γδ T lymphocytes. J Neurooncol. 2021 Jul;153(3):403-415. [Content Brief]
- [4]. Nguyen K,et al. The butyrophilin 3A1 intracellular domain undergoes a conformational change involving the juxtamembrane region. FASEB J. 2017 Nov;31(11):4697-4706. [Content Brief]
