39731-05-0
39731-05-0
Chemical Structure
Carpindolol
Synonym(s): SDZ21009
- CAS No.: 39731-05-0
- Formula:C19H28N2O4
- Molecular Weight:348.44
IUPAC Name: isopropyl 4-(3-(tert-butylamino)-2-hydroxypropoxy)-1H-indole-2-carboxylate
InChIKey: SJYFDORQYYEJLB-UHFFFAOYSA-N
SMILES: O=C(C(N1)=CC2=C1C=CC=C2OCC(O)CNC(C)(C)C)OC(C)C
Biological Activity: Carpindolol (SDZ21009) is a 5-HT1B receptor antagonist (pKd of 8.53 and pKB of 8.0) and a 5-HT1D receptor agonist (pEC50 of 5.91 and pKd of 6.37)[1].
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Carpindolol | Carpindolol (SDZ21009) is a 5-HT1B receptor antagonist (pKd of 8.53 and pKB of 8.0) and a 5-HT1D receptor agonist (pEC50 of 5.91 and pKd of 6.37). | |||||||||||||||||||||
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References
- [1]. P Schoeffter, et al. 5-Hydroxytryptamine 5-HT1B and 5-HT1D receptors mediating inhibition of adenylate cyclase activity. Pharmacological comparison with special reference to the effects of yohimbine, rauwolscine and some beta-adrenoceptor antagonists. Naunyn Schmiedebergs Arch Pharmacol. 1989 Sep;340(3):285-92. [Content Brief]
Keywords
