401904-75-4
401904-75-4
Chemical Structure
Carotegrast
Synonym(s): HCA2969
- CAS No.: 401904-75-4
- Formula:C27H24Cl2N4O5
- Molecular Weight:555.41
IUPAC Name: (S)-2-(2,6-dichlorobenzamido)-3-(4-(6-(dimethylamino)-1-methyl-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)phenyl)propanoic acid
InChIKey: YQKBOUPIOWUMTE-NRFANRHFSA-N
SMILES: O=C(O)[C@@H](NC(C1=C(Cl)C=CC=C1Cl)=O)CC2=CC=C(N3C(N(C)C4=C(C=C(N(C)C)C=C4)C3=O)=O)C=C2
Biological Activity: Carotegrast (HCA2969) is an orally active α4 integrin inhibitor with anti-inflammatory activity. Carotegrast can be used in the research of inflammation-related diseases, such as ulcerative colitis[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Carotegrast | 98.93% | Carotegrast (HCA2969) is an orally active α4 integrin inhibitor with anti-inflammatory activity. Carotegrast can be used in the research of inflammation-related diseases, such as ulcerative colitis. | ||||||||||||||||||||
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References
- [1]. Kazuyuki S, et al. Preparation of novel phenylalanine derivatives as α4 integrin inhibitors. WO 2003070709 A1
- [2]. Cheng Y, et al. Application of a PBPK model to elucidate the changes of systemic and liver exposures for rosuvastatin, carotegrast, and bromfenac followed by OATP inhibition in monkeys. Clin Transl Sci. 2021 Sep;14(5):1924-1934. [Content Brief]
