40680-87-3
Chemical Structure
Piprofurol
- CAS No.: 40680-87-3
- Formula:C26H33NO6
- Molecular Weight:455.54
IUPAC Name: 4-(3-(4,7-dimethoxy-6-(2-(piperidin-1-yl)ethoxy)benzofuran-5-yl)-3-hydroxypropyl)phenol
InChIKey: LIAPJIQUUKLLDZ-UHFFFAOYSA-N
SMILES: OC(C1=C(C(OC)=C2OC=CC2=C1OC)OCCN3CCCCC3)CCC4=CC=C(C=C4)O
Biological Activity: Piprofurol is a calcium channel inhibitor. Piprofurol inhibits the calcium-induced contractions in isolated potassium depolarized preparations of rat aorta in a concentration-dependent manner and relaxes the K+-induced contraction of the dog coronary artery and the rabbit basilar artery. Piprofurol exerts a negative inotropic effect on guinea-pig papillary muscle, with the EC50 of 5 μM[1].
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Piprofurol | Piprofurol is a calcium channel inhibitor. Piprofurol inhibits the calcium-induced contractions in isolated potassium depolarized preparations of rat aorta in a concentration-dependent manner and relaxes the K+-induced contraction of the dog coronary artery and the rabbit basilar artery. Piprofurol exerts a negative inotropic effect on guinea-pig papillary muscle, with the EC50 of 5 μM. | |||||||||||||||||||||
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