409085-42-3
Chemical Structure
NF(N-Me)GA(N-Me)IL
Synonym(s): Amylin (22-27) [NMeG24, NMeI26], human (IAPP)
- CAS No.: 409085-42-3
- Formula:C32H51N7O8
- Molecular Weight:661.79
InChIKey: QKIYXOQZMBTDDJ-PKMOWMNGSA-N
SMILES: O=C([C@@H](N)CC(N)=O)N[C@H](C(N(CC(N[C@H](C(N([C@H](C(N[C@H](C(O)=O)CC(C)C)=O)[C@H](CC)C)C)=O)C)=O)C)=O)CC1=CC=CC=C1
Biological Activity: NF(N-Me)GA(N-Me)IL is a biological active peptide. (This amino acids 22 to 27 fragment is a modification of the human islet amyloid polypeptide hIAPP (NFGAIL) with N-methylation of the amide bonds at G24 and I26. The introduction of two N-methyl rests in the amyloid-core-containing sequence NFGAIL converts this amyloidogenic and cytotoxic sequence into non-amyloidogenic and non-cytotoxic peptide. The peptide is able to bind with high-affinity full-length hIAPP and to inhibit its fibrillogenesis.)
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NF(N-Me)GA(N-Me)IL | NF(N-Me)GA(N-Me)IL is a biological active peptide. (This amino acids 22 to 27 fragment is a modification of the human islet amyloid polypeptide hIAPP (NFGAIL) with N-methylation of the amide bonds at G24 and I26. The introduction of two N-methyl rests in the amyloid-core-containing sequence NFGAIL converts this amyloidogenic and cytotoxic sequence into non-amyloidogenic and non-cytotoxic peptide. The peptide is able to bind with high-affinity full-length hIAPP and to inhibit its fibrillogenesis.) | |||||||||||||||||||||
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Keywords
