445218-34-8
445218-34-8
Chemical Structure
CNS-11
- CAS No.: 445218-34-8
- Formula:C25H21N3O2
- Molecular Weight:395.45
InChIKey: MVMNMAWCMNMLEC-UHFFFAOYSA-N
SMILES: O=C1C2=C(C3=CC=C2)C(C4=CC=CC=C34)=NN1CC(NC(C(C)=CC(C)=C5)=C5C)=O
Biological Activity: CNS-11 is a brain-penetrant tau fibril-degrading compound. CNS-11 reduces α-synuclein. CNS-11 can be used in Alzheimer's and Parkinson's disease research[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CNS-11 | 98.30% | CNS-11 is a brain-penetrant tau fibril-degrading compound. CNS-11 reduces α-synuclein. CNS-11 can be used in Alzheimer's and Parkinson's disease research. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.58
HY-147027PARP-1-IN-2 -
Similarity Score 0.56
HY-153590PARP-1-IN-4 -
Similarity Score 0.56
HY-164713PARP1-IN-31 -
Similarity Score 0.52
HY-147030PARP1-IN-8 -
Similarity Score 0.50
HY-125381CFTR corrector 2 -
Similarity Score 0.48
HY-D0287Solvent red 52 -
Similarity Score 0.47
HY-145855J-1063 -
Similarity Score 0.46
HY-157390DPP-4-IN-9 -
Similarity Score 0.46
HY-168990Ontunisertib -
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References
- [1]. Paul M Seidler, et al. Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro. Nat Commun. 2022 Sep 16;13(1):5451. [Content Brief]
- [2]. Murray KA, et al. Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils. Proc Natl Acad Sci U S A. 2023 Feb 14;120(7):e2217835120. [Content Brief]
