4758-99-0
4758-99-0
Chemical Structure
Guanfu base H
Synonym(s): Atisinium chloride
- CAS No.: 4758-99-0
- Formula:C22H34ClNO2
- Molecular Weight:379.96
InChIKey: CTQGDDPQMCXQJW-NWDYWHSLSA-M
SMILES: O[C@H]1[C@]23[C@](C[C@@](CC3)([H])C1=C)([H])[C@]45[C@]([C@](C[N+](CCO)=C4)(CCC5)C)([H])CC2.[Cl-]
Biological Activity: Guanfu base H (Atisinium chloride) is a diterpenoid alkaloid isolated from Aconitum coreanum and has antiplasmodial activity against the malarial Plasmodium falciparum strains TM4/8.2 (wild type) and K1CB1 with IC50 values of 4 μM and 3.6 μM, respectively[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Guanfu base H | 99.80% | Guanfu base H (Atisinium chloride) is a diterpenoid alkaloid isolated from Aconitum coreanum and has antiplasmodial activity against the malarial Plasmodium falciparum strains TM4/8.2 (wild type) and K1CB1 with IC50 values of 4 μM and 3.6 μM, respectively. | ||||||||||||||||||||
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References
- [1]. WU Qiong, et al. Simultaneous Determination of Guanfu Base A,Guanfu Base I and Guanfu Base H in Radix Aconitum coreanum(Lévl) Rapaics by RP-HPLC. Progress in Pharmaceutical Sciences. 2011, 35(5), 230-233.
- [2]. Wangchuk P, et al. Antiplasmodial activity of atisinium chloride from the Bhutanese medicinal plant, Aconitum orochryseum. J Ethnopharmacol. 2010 Aug 9;130(3):559-62. [Content Brief]
