47896-63-9
Chemical Structure
Angiotensin I/II (1-6)
- CAS 番号: 47896-63-9
- Formula:C36H55N11O10
- Molecular Weight:801.89
IUPAC Name: (2S,5S,8S,11S,14S,17S)-2-((1H-imidazol-4-yl)methyl)-17-amino-5-((S)-sec-butyl)-14-(3-guanidinopropyl)-8-(4-hydroxybenzyl)-11-isopropyl-4,7,10,13,16-pentaoxo-3,6,9,12,15-pentaazanonadecanedioic acid
InChIKey: SYDDLSICWJNDAM-GKUXVWPZSA-N
SMILES: O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC2=CNC=N2)C(O)=O)=O)=O)=O)=O)[C@H](CC(O)=O)N
Biological Activity: Angiotensin I/II 1-6 contains the amino acids 1-6 and is converted from Angiotensin I/II peptide. The precursor angiotensinogen is cleaved by renin to form angiotensin I. Angiotensin I ishydrolyzed by angiotensin-converting enzyme (ACE) to form the biologically active angiotensin II. Angiotensin II has been investigated for the treatment, basic science, and diagnostic of Hypertension, Renin Angiotensin System, and Idiopathic Membranous Nephropathy[1][2][3].
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Angiotensin I/II (1-6) | Angiotensin I/II 1-6 contains the amino acids 1-6 and is converted from Angiotensin I/II peptide. The precursor angiotensinogen is cleaved by renin to form angiotensin I. Angiotensin I ishydrolyzed by angiotensin-converting enzyme (ACE) to form the biologically active angiotensin II. Angiotensin II has been investigated for the treatment, basic science, and diagnostic of Hypertension, Renin Angiotensin System, and Idiopathic Membranous Nephropathy. | |||||||||||||||||||||
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References
- [1]. Erdös EG, et al. Conversion of angiotensin I to angiotensin II. Am J Med. 1976 May 31;60(6):749-59. [Content Brief]
- [2]. Busse LW, et al. Clinical Experience With IV Angiotensin II Administration: A Systematic Review of Safety. Crit Care Med. 2017;45(8):1285-1294. [Content Brief]
- [3]. Angiotensin II
