479-12-9
479-12-9
Chemical Structure
Coumestan
- CAS No.: 479-12-9
- Formula:C15H8O3
- Molecular Weight:236.22
InChIKey: JBIZUYWOIKFETJ-UHFFFAOYSA-N
SMILES: O=C1C2=C(C3=C(O1)C=CC=C3)OC4=C2C=CC=C4
Biological Activity: Coumestan is a secondary metabolite found in leguminous plants and can be used as drug intermediate Coumestan can be used to synthesize various coumarin compounds such as Coumestrol (HY-N2335), Glytabastan B, and Coumestan Pks13 inhibitor. Coumestans can be used for the study of anti-cancer, anti-inflammatory, anti-oxidative, antibacterial, neuroprotective and organ protective[1][2][3][4][5].
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Coumestan | Coumestan is a secondary metabolite found in leguminous plants and can be used as drug intermediate Coumestan can be used to synthesize various coumarin compounds such as Coumestrol (HY-N2335), Glytabastan B, and Coumestan Pks13 inhibitor. Coumestans can be used for the study of anti-cancer, anti-inflammatory, anti-oxidative, antibacterial, neuroprotective and organ protective. | |||||||||||||||||||||
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References
- [1]. Tabbasum MT, R S. Emerging Coumestans in Cancer Therapy With Mechanistic Insights and Clinical Potential. Arch Pharm (Weinheim). 2025 Jul;358(7):e70058. doi: 10.1002/ardp.70058. [Content Brief]
- [2]. Kim JE, et al. Coumestrol Epigenetically Suppresses Cancer Cell Proliferation: Coumestrol Is a Natural Haspin Kinase Inhibitor. Int J Mol Sci. 2017 Oct 24;18(10):2228. [Content Brief]
- [3]. Lun S, et al. Therapeutic potential of coumestan Pks13 inhibitors for tuberculosis. Antimicrob Agents Chemother. 2023 May 1;95(5):e02190-20. [Content Brief]
- [4]. Seong SH, et al. Phytoestrogen Coumestrol Selectively Inhibits Monoamine Oxidase-A and Amyloid β Self-Aggregation. Nutrients. 2022 Sep 16;14(18):3822. [Content Brief]
- [5]. Djafarou S, Boulebd H. The radical scavenger capacity and mechanism of prenylated coumestan-type compounds: a DFT analysis. Free Radic Res. 2022 Mar-Apr;56(3-4):273-281. [Content Brief]
Keywords
