481-70-9
481-70-9
Chemical Structure
Endocrocin
- CAS No.: 481-70-9
- Formula:C16H10O7
- Molecular Weight:314.25
IUPAC Name: 1,6,8-trihydroxy-3-methyl-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid
InChIKey: UZOHDKGTYVTYDZ-UHFFFAOYSA-N
SMILES: O=C(C(C(O)=C1C2=O)=C(C)C=C1C(C3=C2C(O)=CC(O)=C3)=O)O
Biological Activity: Endocrocin is an anthraquinone fungal secondary metabolite. Endocrocin inhibits the recruitment and migration of neutrophils, and enhances the pathogenicity and virulence of Fumagillin (HY-B0751) in Drosophila. Endocrocin can be used in research related to invasive aspergillosis, viral infections and liver diseases[1][2][3][4].
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Endocrocin | Endocrocin is an anthraquinone fungal secondary metabolite. Endocrocin inhibits the recruitment and migration of neutrophils, and enhances the pathogenicity and virulence of Fumagillin (HY-B0751) in Drosophila. Endocrocin can be used in research related to invasive aspergillosis, viral infections and liver diseases. | |||||||||||||||||||||
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References
- [1]. Berthier E, et al. Low-volume toolbox for the discovery of immunosuppressive fungal secondary metabolites. PLoS pathogens. 2013;9(4):e1003289. [Content Brief]
- [2]. Lim FY, et al. Genome-based cluster deletion reveals an endocrocin biosynthetic pathway in Aspergillus fumigatus. Applied and environmental microbiology. 2012 Jun;78(12):4117-25. [Content Brief]
- [3]. Sun L, et al. Metabolic engineering of Saccharomyces cerevisiae for efficient production of endocrocin and emodin. Metabolic engineering. 2019 Jul;54:212-221.
- [4]. Throckmorton K, et al. Redundant synthesis of a conidial polyketide by two distinct secondary metabolite clusters in Aspergillus fumigatus. Environmental microbiology. 2016 Jan;18(1):246-59. [Content Brief]
