487-24-1
Chemical Structure
Pratol
Synonym(s): 7-Hydroxy-4'-methoxyflavone
- CAS No.: 487-24-1
- Formula:C16H12O4
- Molecular Weight:268.26
IUPAC Name: 7-hydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one
InChIKey: SQVXWIUVAILQRH-UHFFFAOYSA-N
SMILES: O=C1C=C(C2=CC=C(OC)C=C2)OC3=CC(O)=CC=C13
Biological Activity: Pratol (7-Hydroxy-4'-methoxyflavone) is an NF-κB inhibitor. Pratol also inhibits NO, PGE2, TNF-α, IL-1β, and IL-6 production. Pratol increases the phosphorylation of p38 MAPK, JNK, and ERK, decreases AKT phosphorylation, and upregulates MITF, tyrosinase, TRP-1, and TRP-2 through a PKA-dependent signaling pathway. Pratol reduces iNOS and COX-2 protein expression, inhibits p65 phosphorylation, and protects IκBα from degradation, thereby inhibiting NF-κB nuclear translocation. Pratol can be used in research on hypopigmentary disorders, inflammatory diseases, cervical cancer, and colon cancer[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Pratol | 99.16% | Pratol (7-Hydroxy-4'-methoxyflavone) is an NF-κB inhibitor. Pratol also inhibits NO, PGE2, TNF-α, IL-1β, and IL-6 production. Pratol increases the phosphorylation of p38 MAPK, JNK, and ERK, decreases AKT phosphorylation, and upregulates MITF, tyrosinase, TRP-1, and TRP-2 through a PKA-dependent signaling pathway. Pratol reduces iNOS and COX-2 protein expression, inhibits p65 phosphorylation, and protects IκBα from degradation, thereby inhibiting NF-κB nuclear translocation. Pratol can be used in research on hypopigmentary disorders, inflammatory diseases, cervical cancer, and colon cancer. | ||||||||||||||||||||
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References
- [1]. Chung YC, et al. Pratol, an O-Methylated Flavone, Induces Melanogenesis in B16F10 Melanoma Cells via p-p38 and p-JNK Upregulation. Molecules. 2017 Oct 11;22(10):1704.
- [2]. Chung YC, et al. Anti‑inflammatory Effect of Pratol in LPS‑stimulated RAW 264.7 Cells via NF‑kB Signaling Pathways. Natural Product Communications. 2018 May 1;13(5).
- [3]. Matsjeh S, et al. Synthesis of 7‑hydroxy‑4’‑methoxyflavanone and 7‑hydroxy‑4’‑methoxyflavone as a candidate anticancer against cervical (HeLa) cancer cell and colon (WiDr) cancer cell by in vitro. AIP Conference Proceedings. 2017 Mar 17;1823:020075.
