488-41-5
Chemical Structure
Mitobronitol
Synonym(s): Myelobromol; DBM
- CAS No.: 488-41-5
- Formula:C6H12Br2O4
- Molecular Weight:307.97
IUPAC Name: (2S,3S,4S,5S)-1,6-dibromohexane-2,3,4,5-tetraol
InChIKey: VFKZTMPDYBFSTM-KVTDHHQDSA-N
SMILES: O[C@@H]([C@H]([C@@H]([C@@H](CBr)O)O)O)CBr
Biological Activity: Mitobronitol (Myelobromol; DBM) is a brominated analog of mannitol, also known as an anticancer agent that is classified as an alkylating agent. Mitobronitol has potential for myelosuppression associated with significantly decreased risk for several complications of allogeneic bone marrow transplantation in accelerated chronic granulocytic leukemia[1][2].
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Mitobronitol | Mitobronitol (Myelobromol; DBM) is a brominated analog of mannitol, also known as an anticancer agent that is classified as an alkylating agent. Mitobronitol has potential for myelosuppression associated with significantly decreased risk for several complications of allogeneic bone marrow transplantation in accelerated chronic granulocytic leukemia. | |||||||||||||||||||||
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- [1]. Silver RT, et al. A comparative study of dibromomannitol and busulfan in the treatment of chronic myeloid leukemia. A study of cancer and leukemia group B. Cancer. 1987 Oct 1;60(7):1442-8. [Content Brief]
- [2]. Szebeni J, et al. Comparison of the lymphoid toxicities of mitobronitol and busulphan in mice: reduced B cell toxicity and improved thymic recovery as possible contributors to the reduced risk for complications following BMT with mitobronitol preconditioning. Leukemia. 1997 Oct;11(10):1769-74. [Content Brief]
Keywords
