491-97-4
Chemical Structure
Thymidine 5′-diphosphate
Synonym(s): dTDP
- CAS No.: 491-97-4
- Formula:C10H16N2O11P2
- Molecular Weight:402.19
IUPAC Name: ((2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl trihydrogen diphosphate
InChIKey: UJLXYODCHAELLY-XLPZGREQSA-N
SMILES: O=C(N1)N([C@H]2C[C@H](O)[C@@H](COP(OP(O)(O)=O)(O)=O)O2)C=C(C)C1=O
Biological Activity: Thymidine 5′-diphosphate (dTDP) is a key product for pyrimidine synthesis in organisms. Thymidine 5′-diphosphate is generated via the phosphorylation of thymidine 5'-monophosphate (dTMP) catalyzed by thymidylate kinase (TMPK), a process requiring ATP and Mg2+. Thymidine 5′-diphosphate is further catalyzed by TMPK into thymidine 5'-triphosphate (dTTP). Detection of Thymidine 5′-diphosphate levels enables the assessment of TMPK activity[1].
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Thymidine 5′-diphosphate | Thymidine 5′-diphosphate (dTDP) is a key product for pyrimidine synthesis in organisms. Thymidine 5′-diphosphate is generated via the phosphorylation of thymidine 5'-monophosphate (dTMP) catalyzed by thymidylate kinase (TMPK), a process requiring ATP and Mg2+. Thymidine 5′-diphosphate is further catalyzed by TMPK into thymidine 5'-triphosphate (dTTP). Detection of Thymidine 5′-diphosphate levels enables the assessment of TMPK activity. | |||||||||||||||||||||
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