499-67-2
Chemical Structure
Proparacaine
Synonym(s): Proxymetacaine
- CAS No.: 499-67-2
- Formula:C16H26N2O3
- Molecular Weight:294.40
IUPAC Name: 2-(diethylamino)ethyl 3-amino-4-propoxybenzoate
InChIKey: KCLANYCVBBTKTO-UHFFFAOYSA-N
SMILES: O=C(OCCN(CC)CC)C1=CC=C(OCCC)C(N)=C1
Biological Activity: Proparacaine (Proxymetacaine) is a local anesthetic. Proparacaine blocks voltage-gated sodium channels on neuronal cell membranes, thereby inhibiting signal conduction and nociceptive signal transmission. Proparacaine blocks nociceptive signals in the eye and induces ocular muscle relaxation to reduce eye movement during surgery. Proparacaine is used in research related to cataracts[1][2][3].
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Proparacaine | Proparacaine (Proxymetacaine) is a local anesthetic. Proparacaine blocks voltage-gated sodium channels on neuronal cell membranes, thereby inhibiting signal conduction and nociceptive signal transmission. Proparacaine blocks nociceptive signals in the eye and induces ocular muscle relaxation to reduce eye movement during surgery. Proparacaine is used in research related to cataracts. | |||||||||||||||||||||
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- [1]. Çalışkan B, et al. The effect of brimonidine and proparacaine on metabolic enzymes: Glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and glutathione reductase. Biotechnol Appl Biochem. 2022;69(1):281-288. [Content Brief]
- [2]. Dang A, et al. An Analysis of the Use of Proparacaine in Cataract Surgery. Cureus. 2022;14(2):e22175. Published 2022 Feb 13. [Content Brief]
- [3]. Chen YW, et al. Adding Dopamine to Proxymetacaine or Oxybuprocaine Solutions Potentiates and Prolongs the Cutaneous Antinociception in Rats. Anesth Analg. 2018;126(5):1721-1728. [Content Brief]
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