506-26-3
Chemical Structure
Gamma-Linolenic acid
Synonym(s): γ-Linolenic acid
- CAS. Nr.: 506-26-3
- Formula:C18H30O2
- Molecular Weight:278.43
IUPAC Name: (6Z,9Z,12Z)-octadeca-6,9,12-trienoic acid
InChIKey: VZCCETWTMQHEPK-QNEBEIHSSA-N
SMILES: CCCCC/C=C\C/C=C\C/C=C\CCCCC(O)=O
Biological Activity: Gamma-linolenic acid (γ-Linolenic acid) is an orally active unsaturated fatty acid. Gamma-linolenic acid exerts anti-inflammatory effects by inhibiting the NF-κB pathway and the phosphorylation of ERK1/2 and JNK. At the same time, it exerts anticancer effects by inducing apoptosis (Apoptosis) in cancer cells. Additionally, Gamma-linolenic acid also has antioxidant and memory-improving effects. It holds promise for research in the fields of inflammation, neurology, and cancer diseases[1][2][3][4][5].
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Gamma-Linolenic acid | 99.80% | Gamma-linolenic acid (γ-Linolenic acid) is an orally active unsaturated fatty acid. Gamma-linolenic acid exerts anti-inflammatory effects by inhibiting the NF-κB pathway and the phosphorylation of ERK1/2 and JNK. At the same time, it exerts anticancer effects by inducing apoptosis (Apoptosis) in cancer cells. Additionally, Gamma-linolenic acid also has antioxidant and memory-improving effects. It holds promise for research in the fields of inflammation, neurology, and cancer diseases. | ||||||||||||||||||||
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Gamma-Linolenic acid (Standard) | 99.92% | Gamma-Linolenic acid (Standard) is the analytical standard of Gamma-Linolenic acid. This product is intended for research and analytical applications. Gamma-linolenic acid (γ-Linolenic acid) is an omega-6 (n-6), 18 carbon (18C-) polyunsaturated fatty acid (PUFA) extracted from Perilla frutescens. Gamma-linolenic acid supplements could restore needed PUFAs and mitigate the disease. | ||||||||||||||||||||
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References
- [1]. Sergeant S, et al. Gamma-linolenic acid, Dihommo-gamma linolenic, Eicosanoids and Inflammatory Processes. Eur J Pharmacol. 2016 Aug 15;785:77-86. [Content Brief]
- [2]. Youn K, et al. Gamma-linolenic acid ameliorates Aβ-induced neuroinflammation through NF-κB and MAPK signalling pathways[J]. Journal of Functional Foods, 2018, 42: 30-37.
- [3]. Andreoli Miyake J, et al. Gamma-Linolenic acid alters migration, proliferation and apoptosis in human and rat glioblastoma cells. Prostaglandins Other Lipid Mediat. 2020 Oct;150:106452. [Content Brief]
- [4]. Rahimi K, et al. The protective effects of Gamma-linolenic acid against indomethacin-induced gastric ulcer in rats[J]. British Journal of Nutrition, 2024, 131(11): 1844-1851. [Content Brief]
- [5]. Khan SA, et al. Gamma-linolenic acid ameliorated glycation-induced memory impairment in rats. Pharm Biol. 2017 Dec;55(1):1817-1823. [Content Brief]
