50816-74-5
50816-74-5
Chemical Structure
Suchilactone
Synonym(s): Jatrophan
- CAS No.: 50816-74-5
- Formula:C21H20O6
- Molecular Weight:368.38
IUPAC Name: (S,E)-3-(benzo[d][1,3]dioxol-5-ylmethylene)-4-(3,4-dimethoxybenzyl)dihydrofuran-2(3H)-one
InChIKey: GVNUFBXIXQNOCF-FUXXUDPSSA-N
SMILES: COC(C=C1C[C@H](COC/2=O)C2=C/C3=CC=C(OCO4)C4=C3)=C(C=C1)OC
Biological Activity: Suchilactone (Jatrophan) is a lignan extracted from Monsonia angustifolia E.Mey. Suchilactone binds to SHP2 and inhibits SHP2 activation, thereby inhibiting ERK-mediated cell proliferation. Suchilactone can be ued in acute myeloid leukaemia (AML)[1].
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Suchilactone | Suchilactone (Jatrophan) is a lignan extracted from Monsonia angustifolia E.Mey. Suchilactone binds to SHP2 and inhibits SHP2 activation, thereby inhibiting ERK-mediated cell proliferation. Suchilactone can be ued in acute myeloid leukaemia (AML). | |||||||||||||||||||||
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References
Keywords
