52365-63-6
Chemical Structure
Dipivefrin
- CAS. Nr.: 52365-63-6
- Formula:C19H29NO5
- Molecular Weight:351.44
IUPAC Name: 4-(1-hydroxy-2-(methylamino)ethyl)-1,2-phenylene bis(2,2-dimethylpropanoate)
InChIKey: OCUJLLGVOUDECM-UHFFFAOYSA-N
SMILES: CC(C)(C(OC1=CC=C(C=C1OC(C(C)(C)C)=O)C(CNC)O)=O)C
Biological Activity: Dipivefrin is an α/β-adrenoceptor agonist and a prodrug of epinephrine. Dipivefrin regulates intraocular pressure by agonizing α/β-adrenoceptors and modulating the aqueous humor outflow pathway. Dipivefrin acts on neuroblastoma cells and downregulates glutamate-induced intracellular calcium levels. Dipivefrin is used in research related to α/β-adrenoceptor-mediated diseases, such as glaucoma[1][2][3][4].
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Dipivefrin | Dipivefrin is an α/β-adrenoceptor agonist and a prodrug of epinephrine. Dipivefrin regulates intraocular pressure by agonizing α/β-adrenoceptors and modulating the aqueous humor outflow pathway. Dipivefrin acts on neuroblastoma cells and downregulates glutamate-induced intracellular calcium levels. Dipivefrin is used in research related to α/β-adrenoceptor-mediated diseases, such as glaucoma. | |||||||||||||||||||||
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References
- [1]. Akaishi T, et al. Ocular hypotensive effects of anti-glaucoma agents in mice. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 2009 Oct;25(5):401-8.
- [2]. Barak S, et al. Targeting the Reconsolidation of Licit Drug Memories to Prevent Relapse: Focus on Alcohol and Nicotine. International journal of molecular sciences. 2021 Apr 15;22(8):4090.
- [3]. Wu KY, et al. Effects of antiglaucoma drugs on cellular proliferation in cultured human corneal keratocytes. The Kaohsiung journal of medical sciences. 2006 Mar;22(3):120-5.
- [4]. Hong SJ, et al. Effects of commercial antiglaucoma drugs to glutamate-induced [Ca2+)]i increase in cultured neuroblastoma cells. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 2003 Jun;19(3):205-15.
