540-12-5
540-12-5
Chemical Structure
Ricinelaidic acid
- CAS No.: 540-12-5
- Formula:C18H34O3
- Molecular Weight:298.46
IUPAC Name: (R,E)-12-hydroxyoctadec-9-enoic acid
InChIKey: WBHHMMIMDMUBKC-XLNAKTSKSA-N
SMILES: OC(CCCCCCC/C=C/C[C@H](O)CCCCCC)=O
Biological Activity: Ricinelaidic acid, a 12-hydroxy fatty acid，is a leukotriene B4 (LTB4) receptor antagonist with the Ki of 2 μM in porcine neutrophil membranes. Ricinelaidic acid inhibits chemotaxis and calcium flux induced by LTB4 in isolated human neutrophils (IC50=10 and 7 μM, respectively). Ricinelaidic acid inhibits bronchoconstriction induced by LTB4 in rats[1].
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Ricinelaidic acid | Ricinelaidic acid, a 12-hydroxy fatty acid，is a leukotriene B4 (LTB4) receptor antagonist with the Ki of 2 μM in porcine neutrophil membranes. Ricinelaidic acid inhibits chemotaxis and calcium flux induced by LTB4 in isolated human neutrophils (IC50=10 and 7 μM, respectively). Ricinelaidic acid inhibits bronchoconstriction induced by LTB4 in rats. | |||||||||||||||||||||
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References
Keywords
