542-32-5
542-32-5
Chemical Structure
Aminoadipic acid
- CAS No.: 542-32-5
- Formula:C6H11NO4
- Molecular Weight:161.16
IUPAC Name: 2-aminohexanedioic acid
InChIKey: OYIFNHCXNCRBQI-UHFFFAOYSA-N
SMILES: O=C(O)C(N)CCCC(O)=O
Biological Activity: Aminoadipic acid is an orally active lysine oxide derivative. Aminoadipic acid induces ROS generation, increases free Ca2+, decreases SOD, and activates TXNIP/NLRP3 pathway. Aminoadipic acid has pro-inflammatory effects. Aminoadipic acid can be used in atherosclerosis research[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Aminoadipic acid | 99.94% | Aminoadipic acid is an orally active lysine oxide derivative. Aminoadipic acid induces ROS generation, increases free Ca2+, decreases SOD, and activates TXNIP/NLRP3 pathway. Aminoadipic acid has pro-inflammatory effects. Aminoadipic acid can be used in atherosclerosis research. | ||||||||||||||||||||
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Aminoadipic acid (Standard) | 99.93% | Aminoadipic acid (Standard) is the analytical standard of Aminoadipic acid. This product is intended for research and analytical applications. Aminoadipic acid is an orally active lysine oxide derivative. Aminoadipic acid induces ROS generation, increases free Ca2+, decreases SOD, and activates TXNIP/NLRP3 pathway. Aminoadipic acid has pro-inflammatory effects. Aminoadipic acid can be used in atherosclerosis research. | ||||||||||||||||||||
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Aminoadipic acid-d6 | Aminoadipic acid-d6 is deuterated labeled Aminoadipic acid (HY-113328). Aminoadipic acid is an intermediate in the metabolism of lysine and glycopurine. | |||||||||||||||||||||
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Aminoadipic acid-d3 | 98.95% | Aminoadipic acid-d3 is the deuterium labeled Aminoadipic acid. Aminoadipic acid is an intermediate in the metabolism of lysine and saccharopine. | ||||||||||||||||||||
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References
- [1]. Wang TJ, et al. 2-Aminoadipic acid is a biomarker for diabetes risk. J Clin Invest. 2013 Oct;123(10):4309-17. [Content Brief]
- [2]. Wang X, et al. α-Aminoadipic acid protects against retinal disruption through attenuating Müller cell gliosis in a rat model of acute ocular hypertension. Drug Des Devel Ther. 2016 Oct 20;10:3449-3457. [Content Brief]
- [3]. Estaras M, et al. The lysine derivative aminoadipic acid, a biomarker of protein oxidation and diabetes-risk, induces production of reactive oxygen species and impairs trypsin secretion in mouse pancreatic acinar cells. Food Chem Toxicol. 2020 Nov;145:111594. [Content Brief]
- [4]. Wang T, et al. Aminoadipic acid aggravates atherosclerotic vascular inflammation through ROS/TXNIP/NLRP3 pathway, a harmful microbial metabolite reduced by paeonol. Int J Biochem Cell Biol. 2024 Dec;177:106678. [Content Brief]
