54397-83-0
Chemical Structure
12(S)-HETE
- CAS No.: 54397-83-0
- Formula:C20H32O3
- Molecular Weight:320.47
IUPAC Name: (S,5Z,8Z,10E,14Z)-12-hydroxyicosa-5,8,10,14-tetraenoic acid
InChIKey: ZNHVWPKMFKADKW-LQWMCKPYSA-N
SMILES: CCCCC/C=C\C[C@H](O)/C=C/C=C\C/C=C\CCCC(O)=O
Biological Activity: 12(S)-HETE is a metabolite of Arachidonic acid, AA (HY-109590). 12(S)-HETE promotes ERK and P38 MAPK phosphorylation, stimulates DNA synthesis and cell proliferation in cancer cells. 12(S)-HETE facilitates wound healing of injured murine-lung-derived microvascular endothelial cell monolayers. 12(S)-HETE can be used for the research of pancreatic cancer[1][2].
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12(S)-HETE | 99.10% | 12(S)-HETE is a metabolite of Arachidonic acid, AA (HY-109590). 12(S)-HETE promotes ERK and P38 MAPK phosphorylation, stimulates DNA synthesis and cell proliferation in cancer cells. 12(S)-HETE facilitates wound healing of injured murine-lung-derived microvascular endothelial cell monolayers. 12(S)-HETE can be used for the research of pancreatic cancer. | ||||||||||||||||||||
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12(S)-HETE-d8 | 12(S)-HETE-d8 contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14 and 15 positions. 12(S)-HETE-d8 is intended for use as an internal standard for the quantification of 12(S)-HETE by GC- or LC-mass spectrometry (MS). 12(S)-HETE-d8 is the predominant lipoxygenase product of mammalian platelets. It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix at 0.1 µM. | |||||||||||||||||||||
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- [1]. Ding XZ, et al. 12-lipoxygenase metabolite 12(S)-HETE stimulates human pancreatic cancer cell proliferation via protein tyrosine phosphorylation and ERK activation. Int J Cancer. 2001;94(5):630-636. [Content Brief]
- [2]. Tang DG, et al. 12(S)-HETE is a mitogenic factor for microvascular endothelial cells: its potential role in angiogenesis. Biochem Biophys Res Commun. 1995;211(2):462-468. [Content Brief]
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