552-54-5
552-54-5
Chemical Structure
Rhamnazin
- CAS. Nr.: 552-54-5
- Formula:C17H14O7
- Molecular Weight:330.29
IUPAC Name: 3,5-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-4H-chromen-4-one
InChIKey: MYMGKIQXYXSRIJ-UHFFFAOYSA-N
SMILES: O=C1C(O)=C(C2=CC=C(O)C(OC)=C2)OC3=CC(OC)=CC(O)=C13
Biological Activity: Rhamnazin is an orally active inhibitor of VEGFR2 signaling with an IC50 of 4.68 μM against VEGFR2 kinase. Rhamnazin shows potent antiangiogenic activity and antitumor efficacy[1]. Rhamnazin shows antioxidant and anti-inflammatory properties[2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Rhamnazin | 99.00% | Rhamnazin is an orally active inhibitor of VEGFR2 signaling with an IC50 of 4.68 μM against VEGFR2 kinase. Rhamnazin shows potent antiangiogenic activity and antitumor efficacy. Rhamnazin shows antioxidant and anti-inflammatory properties. | ||||||||||||||||||||
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Dillenetin | Dillenetin is a flavonoid. Dillenetin can be isolated from the fruit of Dillenia indica. Dillenetin has anticancer activity against lung cancer and cervical cancer. | |||||||||||||||||||||
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Isorhamnetin (Standard) | ≥98% | Isorhamnetin (Standard) is the analytical standard of Isorhamnetin. This product is intended for research and analytical applications. Isorhamnetin is a flavonoid compound extracted from the Chinese herb Hippophae rhamnoides L.. Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3K. | ||||||||||||||||||||
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Tamarixetin (Standard) | ≥98% | Tamarixetin (Standard) is the analytical standard of Tamarixetin. This product is intended for research and analytical applications. Tamarixetin (4'-O-Methyl Quercetin) is an orally active natural flavonoid derivative of quercetin and caseinolytic protease p (ClpP) inhibitor with anti-inflammatory, antioxidant and antitumor effects. Tamarixetin inhibits the hydrolytic activity of ClpP to the fluorescent substrate Suc-LY-AMC with an IC50 of 49.73 μM, which can be used for the study of Staphylococcus aureus infection. Tamarixetin inhibits tumor cell growth, induces apoptosis, and cell cycle arrest. Tamarixetin prevents cardiac hypertrophy by inhibiting the NFAT and AKT pathways. | ||||||||||||||||||||
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Quercetin 5,3′-dimethyl ether | Quercetin 5,3′-dimethyl ether is a kind of flavonoid. Quercetin 5,3′-dimethyl ether can be isolated from Combretum erythrophyllum (Combretaceae). Quercetin 5,3′-dimethyl ether has anti-inflammatory activity and antibacterial activity. | |||||||||||||||||||||
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Quercetin 3,7-dimethyl ether | 99.34% | Quercetin 3,7-dimethyl ether, isolated from Croton schiedeanus Schlecht, has a NO/cGMP pathway-related profile, with increased vasorelaxant activity. | ||||||||||||||||||||
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Pachypodol | 99.82% | Pachypodol is an orally active methoxyflavonoid compound. Pachypodol activates the ERK-dependent Nrf2 pathway and inhibits Apoptosis. Pachypodol exhibits activities such as antioxidant, cytoprotective, anti-inflammatory effects. Pachypodol improves cognition. Pachypodol exerts protective effects against cardiac and liver damage. Pachypodol has anticancer activity against colon cancer. | ||||||||||||||||||||
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Ombuin | 99.31% | Ombuin, isolated from Zanthoxylum armatum, displays broad spectrum antibacterial effect with MIC ranges from 125 to 500 μg/mL. | ||||||||||||||||||||
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Rhamnetin (Standard) | ≥98% | Rhamnetin (Standard) is the analytical standard of Rhamnetin. This product is intended for research and analytical applications. Rhamnetin is a quercetin derivative found in Coriandrum sativum, inhibits secretory phospholipase A2 and histone deacetylase 2 (HDAC2). Rhamnetin exhibits antitumor, antioxidant and anti-inflammatory activity. | ||||||||||||||||||||
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3',4',7-Trimethoxyquercetin | 98.87% | 3',4',7-Trimethoxyquercetin (Quercetin 3′,4′,7-trimethyl ether) is a polymethoxyflavonoid that can be isolated from Taraxacum mongolicum. 3',4',7-Trimethoxyquercetin is also a derivative of Quercetin hydrate (HY-18085A). 3',4',7-Trimethoxyquercetin has anti-tumor activity. | ||||||||||||||||||||
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Quercetin 3,3'-dimethyl ether | 99.04% | Quercetin 3,3'-dimethyl ether possesses antioxidant acticity. | ||||||||||||||||||||
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References
- [1]. Yu Y, et al. Rhamnazin, a novel inhibitor of VEGFR2 signaling with potent antiangiogenic activity and antitumor efficacy. Biochem Biophys Res Commun. 2015 Mar 20;458(4):913-9. [Content Brief]
- [2]. Wu G, et al. ANTIOXIDANT AND ANTI-INFLAMMATORY EFFECTS OF RHAMNAZIN ON LIPOPOLYSACCHARIDE-INDUCED ACUTE LUNG INJURY AND INFLAMMATION IN RATS. Afr J Tradit Complement Altern Med. 2017 Jun 5;14(4):201-212. [Content Brief]
