56980-93-9
56980-93-9
Chemical Structure
Celiprolol
Synonym(s): REV 5320
- CAS No.: 56980-93-9
- Formula:C20H33N3O4
- Molecular Weight:379.49
IUPAC Name: 3-(3-acetyl-4-(3-(tert-butylamino)-2-hydroxypropoxy)phenyl)-1,1-diethylurea
InChIKey: JOATXPAWOHTVSZ-UHFFFAOYSA-N
SMILES: O=C(N(CC)CC)NC1=CC=C(C(C(C)=O)=C1)OCC(CNC(C)(C)C)O
Biological Activity: Celiprolol (REV 5320) is a potent, cardioselective and orally active β1-andrenoceptor r antagonist with partial β2 agonist activity, with Ki values of 0.14-8.3 μM. Celiprolol has antihypertensive and antianginal activity, and can be used for the research of cardiovascular disease such as high blood pressure[1][4].
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Celiprolol | Celiprolol (REV 5320) is a potent, cardioselective and orally active β1-andrenoceptor r antagonist with partial β2 agonist activity, with Ki values of 0.14-8.3 μM. Celiprolol has antihypertensive and antianginal activity, and can be used for the research of cardiovascular disease such as high blood pressure. | |||||||||||||||||||||
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References
- [1]. James J Nawarskas, et, al. Celiprolol: A Unique Selective Adrenoceptor Modulator. Cardiol Rev. Sep/Oct 2017; 25(5): 247-253. [Content Brief]
- [4]. R G Van Inwegen, et al. Effects of celiprolol (REV 5320), a new cardioselective beta-adrenoceptor antagonist, on in vitro adenylate cyclase, alpha- and beta-adrenergic receptor binding and lipolysis. Arch Int Pharmacodyn Ther. 1984 Nov;272(1):40-55. [Content Brief]
