575474-82-7
575474-82-7
Chemical Structure
R112
- CAS No.: 575474-82-7
- Formula:C16H13FN4O2
- Molecular Weight:312.30
IUPAC Name: 3,3'-((5-fluoropyrimidine-2,4-diyl)bis(azanediyl))diphenol
InChIKey: TVKGTSHBQZEFEE-UHFFFAOYSA-N
SMILES: FC1=CN=C(NC2=CC(O)=CC=C2)N=C1NC3=CC(O)=CC=C3
Biological Activity: R112 is a fast and reversible inhibitor of spleen tyrosine kinase (Syk) kinase. R112 inhibits Syk kinase activity with an IC50 value of 226 nM and a Ki value of 96 nM. R112 inhibits IgE-FcεRI signaling pathway. R112 can be used for the research of allergic rhinitis[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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R112 | 98.90% | R112 is a fast and reversible inhibitor of spleen tyrosine kinase (Syk) kinase. R112 inhibits Syk kinase activity with an IC50 value of 226 nM and a Ki value of 96 nM. R112 inhibits IgE-FcεRI signaling pathway. R112 can be used for the research of allergic rhinitis. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.76
HY-111138CZC-8004 -
Similarity Score 0.75
HY-164454AJI-100 -
Similarity Score 0.74
HY-123469RS-0466 -
Similarity Score 0.73
HY-114884RS-0406 -
Similarity Score 0.69
HY-15737DB07268 -
Similarity Score 0.69
HY-160688GW759710A -
Similarity Score 0.66
HY-14535SEN-1269 -
Similarity Score 0.63
HY-164455AJI-214 -
Similarity Score 0.62
HY-15769AWHI-P180 hydrochloride -
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