575474-82-7
575474-82-7
Chemical Structure
R112
- CAS No.: 575474-82-7
- Formula:C16H13FN4O2
- Molecular Weight:312.30
IUPAC Name: 3,3'-((5-fluoropyrimidine-2,4-diyl)bis(azanediyl))diphenol
InChIKey: TVKGTSHBQZEFEE-UHFFFAOYSA-N
SMILES: FC1=CN=C(NC2=CC(O)=CC=C2)N=C1NC3=CC(O)=CC=C3
Biological Activity: R112 is a fast and reversible inhibitor of spleen tyrosine kinase (Syk) kinase. R112 inhibits Syk kinase activity with an IC50 value of 226 nM and a Ki value of 96 nM. R112 inhibits IgE-FcεRI signaling pathway. R112 can be used for the research of allergic rhinitis[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
R112 | 98.90% | R112 is a fast and reversible inhibitor of spleen tyrosine kinase (Syk) kinase. R112 inhibits Syk kinase activity with an IC50 value of 226 nM and a Ki value of 96 nM. R112 inhibits IgE-FcεRI signaling pathway. R112 can be used for the research of allergic rhinitis. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
Keywords
