57784-96-0
57784-96-0
Chemical Structure
Forphenicine
- CAS No.: 57784-96-0
- Formula:C9H9NO4
- Molecular Weight:195.17
InChIKey: MWSKDGPKFCWPOF-QMMMGPOBSA-N
SMILES: OC([C@H](C1=CC(O)=C(C=C1)C=O)N)=O
Biological Activity: Forphenicine is a bacterial metabolite that is found in S. fulvoviridis and an inhibitor of alkaline phosphatase. Forphenicine inhibits the growth of HL-60 leukemia cells at 10 µM. Forphenicine also increases survival in a guinea pig model of experimental autoimmune encephalomyelitis (EAE)[1][2].
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Forphenicine | Forphenicine is a bacterial metabolite that is found in S. fulvoviridis and an inhibitor of alkaline phosphatase. Forphenicine inhibits the growth of HL-60 leukemia cells at 10 µM. Forphenicine also increases survival in a guinea pig model of experimental autoimmune encephalomyelitis (EAE). | |||||||||||||||||||||
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References
- [1]. Miura K, et al. Effects of enzyme inhibitors in inhibiting the growth and inducing the differentiation of human promyelocytic leukemia cells, HL-60. J Antibiot (Tokyo). 1986 May;39(5):734-5. [Content Brief]
- [2]. Aoyagi T, et al. Forphenicine, and inhibitor of alkaline phosphatase produced by actinomycetes. J Antibiot (Tokyo). 1978 Mar;31(3):244-6. [Content Brief]
Keywords
