58893-33-7
58893-33-7
Chemical Structure
ICRF 192
- CAS No.: 58893-33-7
- Formula:C12H18N4O4
- Molecular Weight:282.30
InChIKey: LYOGHIFIHCGJCM-UHFFFAOYSA-N
SMILES: O=C1NC(CN(CC(CC)N2CC(NC(C2)=O)=O)C1)=O
Biological Activity: ICRF 192 is a weak DNA topoisomerase II (DNA topoisomerase II) inhibitor with an IC50 of 91 μM. ICRF 192 forms an iron-chelating derivative via ring-opening hydrolysis, which can displace Fe3+ from the Fe3+-doxorubicin complex. ICRF 192 is used for studies on the structure-activity relationship of bisdioxopiperazines and the cardiotoxicity of anthracycline drugs[1][2][3].
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ICRF 192 | ICRF 192 is a weak DNA topoisomerase II (DNA topoisomerase II) inhibitor with an IC50 of 91 μM. ICRF 192 forms an iron-chelating derivative via ring-opening hydrolysis, which can displace Fe3+ from the Fe3+-doxorubicin complex. ICRF 192 is used for studies on the structure-activity relationship of bisdioxopiperazines and the cardiotoxicity of anthracycline drugs. | |||||||||||||||||||||
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References
- [1]. Herman EH, et al. Comparison of the protective effects against chronic doxorubicin cardiotoxicity and the rates of iron (III) displacement reactions of ICRF-187 and other bisdiketopiperazines. Cancer chemotherapy and pharmacology. 1997;40(5):400-408. [Content Brief]
- [2]. Dawson KM. Studies on the stability and cellular distribution of dioxopiperazines in cultured BHK-21S cells. Biochem Pharmacol. 1975 Dec 15;24(24):2249-2253. [Content Brief]
- [3]. Hasinoff BB, et al. A QSAR study comparing the cytotoxicity and DNA topoisomerase II inhibitory effects of bisdioxopiperazine analogs of ICRF-187 (dexrazoxane). Biochemical pharmacology. 1995 Sep 28;50(7):953-958. [Content Brief]
