612487-72-6
612487-72-6
Chemical Structure
AZD1080
- CAS No.: 612487-72-6
- Formula:C19H18N4O2
- Molecular Weight:334.37
IUPAC Name: 2-hydroxy-3-(5-(morpholinomethyl)pyridin-2-yl)-1H-indole-5-carbonitrile
InChIKey: BLTVBQXJFVRPFK-UHFFFAOYSA-N
SMILES: OC(N1)=C(C2=CC=C(CN3CCOCC3)C=N2)C4=C1C=CC(C#N)=C4
Biological Activity: AZD1080 is a potent and selective GSK3 inhibitor. AZD1080 inhibits recombinant human GSK3α and GSK3β with pKi (IC50) of 8.2 (6.9 nM) and 7.5 (31 nM), respectively.
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AZD1080 | 99.16% | AZD1080 is a potent and selective GSK3 inhibitor. AZD1080 inhibits recombinant human GSK3α and GSK3β with pKi (IC50) of 8.2 (6.9 nM) and 7.5 (31 nM), respectively. | ||||||||||||||||||||
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AZD1080-d8 | AZD1080-d8 is the deuterium labeled AZD1080 (HY-13862). AZD1080 is a potent and selective GSK3 inhibitor. AZD1080 inhibits recombinant human GSK3α and GSK3β with pKi (IC50) of 8.2 (6.9 nM) and 7.5 (31 nM), respectively. | |||||||||||||||||||||
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Keywords
