612487-72-6
612487-72-6
Chemical Structure
AZD1080
- CAS No.: 612487-72-6
- Formula:C19H18N4O2
- Molecular Weight:334.37
IUPAC Name: 2-hydroxy-3-(5-(morpholinomethyl)pyridin-2-yl)-1H-indole-5-carbonitrile
InChIKey: BLTVBQXJFVRPFK-UHFFFAOYSA-N
SMILES: OC(N1)=C(C2=CC=C(CN3CCOCC3)C=N2)C4=C1C=CC(C#N)=C4
Biological Activity: AZD1080 is a potent and selective GSK3 inhibitor. AZD1080 inhibits recombinant human GSK3α and GSK3β with pKi (IC50) of 8.2 (6.9 nM) and 7.5 (31 nM), respectively.
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AZD1080 | 99.16% | AZD1080 is a potent and selective GSK3 inhibitor. AZD1080 inhibits recombinant human GSK3α and GSK3β with pKi (IC50) of 8.2 (6.9 nM) and 7.5 (31 nM), respectively. | ||||||||||||||||||||
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AZD1080-d8 | AZD1080-d8 is the deuterium labeled AZD1080 (HY-13862). AZD1080 is a potent and selective GSK3 inhibitor. AZD1080 inhibits recombinant human GSK3α and GSK3β with pKi (IC50) of 8.2 (6.9 nM) and 7.5 (31 nM), respectively. | |||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.55
HY-147329RAGE 229 -
Similarity Score 0.53
HY-178926RAGE406R -
Similarity Score 0.49
HY-12477PF-06447475 -
Similarity Score 0.49
HY-148852PNU-183792 -
Similarity Score 0.49
HY-15883GNE-900 -
Similarity Score 0.49
HY-173291Tau ligand-1 -
Similarity Score 0.48
HY-149258KWCN-41 -
Similarity Score 0.47
HY-156511ETC-168 -
Similarity Score 0.47
HY-15797UNC2250 -
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