622795-76-0
622795-76-0
Chemical Structure
PIP-199
- CAS 番号: 622795-76-0
- Formula:C27H28N4O3
- Molecular Weight:456.54
IUPAC Name: ethyl 4-((1-hydroxy-2-phenyl-1H-indol-3-yl)(pyridin-2-yl)methyl)piperazine-1-carboxylate
InChIKey: ROTCTSYSZSYNHB-UHFFFAOYSA-N
SMILES: O=C(N1CCN(C(C2=C(C3=CC=CC=C3)N(O)C4=C2C=CC=C4)C5=NC=CC=C5)CC1)OCC
Biological Activity: PIP-199 is a selective inhibitor of RMI (RecQ-mediated genome instability protein) core complex/MM2 interaction, with an IC50 of 36 μM. PIP-199 can be used for the research of sensitizing resistant tumors to DNA crosslinking chemotherapeutics[1].
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PIP-199 | 98.0% | PIP-199 is a selective inhibitor of RMI (RecQ-mediated genome instability protein) core complex/MM2 interaction, with an IC50 of 36 μM. PIP-199 can be used for the research of sensitizing resistant tumors to DNA crosslinking chemotherapeutics. | ||||||||||||||||||||
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