1. Cell Cycle/DNA Damage
  2. DNA Alkylator/Crosslinker
  3. PIP-199

PIP-199 

Cat. No.: HY-124325 Purity: >98.0%
Handling Instructions

PIP-199 is a selective inhibitor of RMI (RecQ-mediated genome instability protein) core complex/MM2 interaction, with an IC50 of 36 μM. MM2 is the binding site of RMI complex on Fanconi anemia complementation group M protein (FANCM). PIP-199 can be used for the research of sensitizing resistant tumors to DNA crosslinking chemotherapeutics.

For research use only. We do not sell to patients.

PIP-199 Chemical Structure

PIP-199 Chemical Structure

CAS No. : 622795-76-0

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Description

PIP-199 is a selective inhibitor of RMI (RecQ-mediated genome instability protein) core complex/MM2 interaction, with an IC50 of 36 μM. MM2 is the binding site of RMI complex on Fanconi anemia complementation group M protein (FANCM). PIP-199 can be used for the research of sensitizing resistant tumors to DNA crosslinking chemotherapeutics[1].

IC50 & Target

RMI core complex/MM2 interaction[1]

In Vitro

Induction of the Fanconi anemia (FA) DNA repair pathway is a common mechanism by which tumors evolve resistance to DNA crosslinking chemotherapies[1].
Proper execution of the FA pathway requires interaction between the FANCM and the RMI complex, and mutations that disrupt FANCM/RMI interactions sensitize cells to DNA crosslinking agents[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

456.54

Formula

C₂₇H₂₈N₄O₃

CAS No.

622795-76-0

SMILES

O=C(N1CCN(C(C2=C(C3=CC=CC=C3)N(O)C4=C2C=CC=C4)C5=NC=CC=C5)CC1)OCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
References

Purity: >98.0%

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Keywords:

PIP-199PIP199PIP 199DNA Alkylator/CrosslinkerFanconianemiaDNArepairprotein-proteininteractionFANCMRMIInhibitorinhibitorinhibit

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PIP-199
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HY-124325
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