62587-73-9
Chemical Structure
Cefsulodin
Synonym(s): SCE-129
- CAS No.: 62587-73-9
- Formula:C22H20N4O8S2
- Molecular Weight:532.55
IUPAC Name: (R)-2-(((6R,7R)-3-((4-carbamoylpyridin-1-ium-1-yl)methyl)-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-7-yl)amino)-2-oxo-1-phenylethane-1-sulfonate
InChIKey: SYLKGLMBLAAGSC-QLVMHMETSA-N
SMILES: O=C(N[C@H]1[C@@]2([H])SCC(C[N+]3=CC=C(C(N)=O)C=C3)=C(C(O)=O)N2C1=O)[C@@H](C4=CC=CC=C4)S(=O)([O-])=O
Biological Activity: Cefsulodin (SCE-129) showed potent activity against Pseudomonas aeruginosa and strains susceptible to penicillin and gentamicin, with effectiveness comparable to that of gentamicin and debendazole. However, its effectiveness was diminished against penicillin-resistant strains of P. aeruginosa, particularly strains that were also resistant to gentamicin. For P. aeruginosa maltofila, SCE-129 showed similar minimum inhibitory concentrations to penicillin, gentamicin, and debendazole. Pseudomonas cepacia strains generally showed moderate resistance to SCE-129 and penicillin, and high resistance to gentamicin and debendazole[1].
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Cefsulodin | Cefsulodin (SCE-129) showed potent activity against Pseudomonas aeruginosa and strains susceptible to penicillin and gentamicin, with effectiveness comparable to that of gentamicin and debendazole. However, its effectiveness was diminished against penicillin-resistant strains of P. aeruginosa, particularly strains that were also resistant to gentamicin. For P. aeruginosa maltofila, SCE-129 showed similar minimum inhibitory concentrations to penicillin, gentamicin, and debendazole. Pseudomonas cepacia strains generally showed moderate resistance to SCE-129 and penicillin, and high resistance to gentamicin and debendazole. | |||||||||||||||||||||
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