6286-09-5
Chemical Structure
NSC10010 hydrochloride
- CAS No.: 6286-09-5
- Formula:C31H42Cl2N4O2
- Molecular Weight:573.60
IUPAC Name: N1,N9-bis(6-methoxy-2-methylquinolin-4-yl)nonane-1,9-diamine dihydrochloride
InChIKey: PYXMJTIQBGOWBI-UHFFFAOYSA-N
SMILES: CC1=NC2=CC=C(OC)C=C2C(NCCCCCCCCCNC3=CC(C)=NC4=CC=C(OC)C=C34)=C1.[H]Cl.[H]Cl
Biological Activity: NSC10010 hydrochloride inhibits gammaherpesvirus associated B-lymphomas growth through activation of NF-kB and c-Myc-mediated signaling pathways. NSC10010 hydrochloride induces necrotic cell death in gammaherpesvirus infected B-cells. NSC10010 hydrochloride is also an inhibitor of Mtb ClpC1 ATPase[1][2].
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NSC10010 hydrochloride | NSC10010 hydrochloride inhibits gammaherpesvirus associated B-lymphomas growth through activation of NF-kB and c-Myc-mediated signaling pathways. NSC10010 hydrochloride induces necrotic cell death in gammaherpesvirus infected B-cells. NSC10010 hydrochloride is also an inhibitor of Mtb ClpC1 ATPase. | |||||||||||||||||||||
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- [1]. Dzeng RK, et al. Small molecule growth inhibitors of human oncogenic gammaherpesvirus infected B-cells. Mol Oncol. 2015 Feb;9(2):365-76. [Content Brief]
- [2]. Amritansh Bhanot, et al. Discovery of small molecule inhibitors of Mycobacterium tuberculosis ClpC1: SAR studies and antimycobacterial evaluation. Results in Chemistry. Volume 5, January 2023, 100904.
Keywords
