63784-08-7
Chemical Structure
Cyclocreatine phosphate dilithium
- CAS No.: 63784-08-7
- Formula:C5H8Li2N3O5P
- Molecular Weight:234.99
IUPAC Name: lithium 2-(3-(hydroxyoxidophosphoryl)-2-iminoimidazolidin-1-yl)acetate
InChIKey: OSEHCDZPWDWMNJ-UHFFFAOYSA-L
SMILES: O=C(CN1C(N(P(O[Li])(O[Li])=O)CC1)=N)O
Biological Activity: Cyclocreatine phosphate dilithium is a synthetic intracellular energy buffer. Cyclocreatine phosphate dilithium mediates antiproliferative activity in cells with high creatine kinase levels and inhibits solid tumor growth. Cyclocreatine phosphate dilithium maintains adenosine triphosphate (ATP) levels and protects tissues from hypoxia, cellular damage and inflammation during ischemic events. Cyclocreatine phosphate dilithium accumulates in skeletal muscle, reduces muscle phosphocreatine and total creatine levels, and acts both as a bioenergetic/anti-inflammatory agent and an experimental tool for the assessment of ischemic injury. Cyclocreatine phosphate dilithium can be used in studies related to solid tumors, heart failure and ischemia[1][2][3].
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Cyclocreatine phosphate dilithium | Cyclocreatine phosphate dilithium is a synthetic intracellular energy buffer. Cyclocreatine phosphate dilithium mediates antiproliferative activity in cells with high creatine kinase levels and inhibits solid tumor growth. Cyclocreatine phosphate dilithium maintains adenosine triphosphate (ATP) levels and protects tissues from hypoxia, cellular damage and inflammation during ischemic events. Cyclocreatine phosphate dilithium accumulates in skeletal muscle, reduces muscle phosphocreatine and total creatine levels, and acts both as a bioenergetic/anti-inflammatory agent and an experimental tool for the assessment of ischemic injury. Cyclocreatine phosphate dilithium can be used in studies related to solid tumors, heart failure and ischemia. | |||||||||||||||||||||
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- [1]. Schimmel L, et al. The synthetic phosphagen cyclocreatine phosphate inhibits the growth of a broad spectrum of solid tumors. Anticancer Res. 1996;16(1):375-380. [Content Brief]
- [2]. Elgebaly SA, et al. Cyclocreatine Phosphate: A Novel Bioenergetic/Anti-Inflammatory Drug That Resuscitates Poorly Functioning Hearts and Protects against Development of Heart Failure. Pharmaceuticals (Basel). 2023;16(3):453. Published 2023 Mar 16. [Content Brief]
- [3]. Turner DM, et al. Enhanced ability of skeletal muscle containing cyclocreatine phosphate to sustain ATP levels during ischemia following beta-adrenergic stimulation. J Biol Chem. 1987;262(14):6605-6609. [Content Brief]
Keywords
