64-95-9
64-95-9
Chemical Structure
Adiphenine
- CAS No.: 64-95-9
- Formula:C20H25NO2
- Molecular Weight:311.42
IUPAC Name: 2-(diethylamino)ethyl 2,2-diphenylacetate
InChIKey: JGOAIQNSOGZNBX-UHFFFAOYSA-N
SMILES: O=C(C(C1=CC=CC=C1)C2=CC=CC=C2)OCCN(CC)CC
Biological Activity: Adiphenine is a non-competitive inhibitor of nicotinic acetylcholine receptor (nAChR), with an IC50s of 1.9, 1.8, 3.7, and 6.3 μM for α1, α3β4, α4β2, and α4β4, respectively. Adiphenine has anticonvulsant effects[1][2][3].
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Adiphenine | Adiphenine is a non-competitive inhibitor of nicotinic acetylcholine receptor (nAChR), with an IC50s of 1.9, 1.8, 3.7, and 6.3 μM for α1, α3β4, α4β2, and α4β4, respectively. Adiphenine has anticonvulsant effects. | |||||||||||||||||||||
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References
- [1]. Gentry CL, et, al. Local anesthetics noncompetitively inhibit function of four distinct nicotinic acetylcholine receptor subtypes. J Pharmacol Exp Ther. 2001 Dec;299(3):1038-48. [Content Brief]
- [2]. Spitzmaul, G., et al., The local anaesthetics proadifen and adiphenine inhibit nicotinic receptors by different molecular mechanisms. Br J Pharmacol, 2009. 157(5): p. 804-17. [Content Brief]
- [3]. TANAKA K, et, al. Anticonvulsant properties of procaine, cocaine, adiphenine and related structures. Proc Soc Exp Biol Med. 1955 Oct;90(1):192-5. [Content Brief]
Keywords
