641-38-3
641-38-3
Chemical Structure
Alternariol
- CAS No.: 641-38-3
- Formula:C14H10O5
- Molecular Weight:258.23
IUPAC Name: 3,7,9-trihydroxy-1-methyl-6H-benzo[c]chromen-6-one
InChIKey: CEBXXEKPIIDJHL-UHFFFAOYSA-N
SMILES: CC1=CC(O)=CC(O2)=C1C3=CC(O)=CC(O)=C3C2=O
Biological Activity: Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Alternariol | 99.79% | Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects. | ||||||||||||||||||||
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Alternariol (Standard) | ≥98% | Alternariol (Standard) is the analytical standard of Alternariol. This product is intended for research and analytical applications. Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects. | ||||||||||||||||||||
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Alternariol-d2 | Alternariol-d2 is deuterium labeled Alternariol. Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects. | |||||||||||||||||||||
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Alternariol-13C14 | 98.9% | Alternariol-13C14 is a 13C labeled Alternariol (HY-N6714). | ||||||||||||||||||||
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4-Hydroxyalternariol | 4-Hydroxyalternariol is an Alternaria metabolite. | |||||||||||||||||||||
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D715-2441 | D715-2441 is an influenza virus RNA polymerase inhibitor (IC50=1.7-4.4 μM). D715-2441 exhibits broad-spectrum antiviral activity against multiple influenza A strains. D715-2441 is promising for research of seasonal influenza and influenza viruses. | |||||||||||||||||||||
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Pulixin | Pulixin prevents FREP1 from binding to P. falciparum-infected cell lysate. Pulixin blocks the transmission of the parasite to mosquitoes with an EC50 of 11 µM. Pulixin also inhibits the proliferation of asexual-stage P. falciparum with an EC50 of 47 nM. | |||||||||||||||||||||
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Norrubrofusarin | 99.64% | Norrubrofusarin (Didemethylasperxanthone) is a natural product that can be obtained by demethylation of the metabolite (Compound III) of Aspergillus nige. | ||||||||||||||||||||
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1,3,5,6-Tetrahydroxy-8-methylxanthone | 1,3,5,6-Tetrahydroxy-8-methylxanthone (compound 8) is a dimeric 1,4-benzoquinone derivative isolated from the marine-derived fungus Penicillium genus. 1,3,5,6-Tetrahydroxy-8-methylxanthone shows distinctive inhibitory activities against nitric oxide production in mouse microglial BV-2 cells. | |||||||||||||||||||||
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Norlichexanthone | 99.79% | Norlichexanthone is a compound isolated from the stem bark of Kandelia candel (L.) Druce, Rhizophoraceae. | ||||||||||||||||||||
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Urolithin M7 | 96.68% | Urolithin M7 is an orally active metabolite, which is generated through gut microbiota metabolism. Urolithin M7 inhibits oxidative stress and modulates inflammatory signaling pathways. Urolithin M7 is promising for research of gut microbiota metabolism and cardiovascular diseases. | ||||||||||||||||||||
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4-Hydroxyalternariol-9-methyl ether | 4-Hydroxyalternariol-9-methyl ether can be isolated from an endolichenic fungal strain Nigrospora sphaerica (No.83-1-1-2), endolichenic fungal strains Alternaria alternata (No.58-8-4-1) and Phialophora sp. (No.96-1-8-1). | |||||||||||||||||||||
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Djalonensone | 99.02% | Djalonensone, isolated from the roots of Anthocleista djalonensis (Loganiaceae), is an important taxonomic marker of the plant species. | ||||||||||||||||||||
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Djalonensone-d3 | Djalonensone-d3 is a deuterium labeled Djalonensone (HY-W013863). Djalonensone, isolated from the roots of Anthocleista djalonensis (Loganiaceae), is an important taxonomic marker of the plant species. | |||||||||||||||||||||
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References
- [1]. Fliszár-Nyúl E, et al. Interaction of Mycotoxin Alternariol with Serum Albumin. Int J Mol Sci. 2019 May 12;20(9). pii: E2352. [Content Brief]
- [2]. Grover S, et al. The Alternaria alternate Mycotoxin Alternariol Suppresses Lipopolysaccharide-Induced Inflammation. Int J Mol Sci. 2017 Jul 20;18(7). pii: E1577. [Content Brief]
- [3]. Eva-Maria Brugger, et al. Mutagenicity of the mycotoxin alternariol in cultured mammalian cells. Toxicol Lett. 2006 Jul 14;164(3):221-30. [Content Brief]
- [4]. Chien-Hsun Huang, et al. Alternariol exerts embryotoxic and immunotoxic effects on mouse blastocysts through ROS-mediated apoptotic processes. Toxicol Res (Camb). 2021 Jun 16;10(4):719-732. [Content Brief]
- [5]. Jian Xin, et al. Alternariol alleviates breast carcinoma by inhibiting cellular proliferation correlated with increased apoptotic events in rats. European Journal of Inflammation.Volume 20: 1–13
