65700-73-4
Chemical Structure
(+)-Naloxone
- CAS No.: 65700-73-4
- Formula:C19H21NO4
- Molecular Weight:327.37
IUPAC Name: (4S,4aR,7aS,12bR)-3-allyl-4a,9-dihydroxy-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one
InChIKey: UZHSEJADLWPNLE-PIKADFDJSA-N
SMILES: O[C@@]12[C@]34C5=C(C[C@]2([H])N(CC4)CC=C)C=CC(O)=C5O[C@]3([H])C(CC1)=O
Biological Activity: (+)-Naloxone is a TLR4 inhibitor and the dextrorotatory enantiomer of the non-opioid Naloxone (HY-17417A) that lacks opioid receptor binding activity. (+)-Naloxone binds to MD2, preventing LPS from binding to TLR4, thereby inhibiting TLR4 signaling, downstream NFκB activation, and proinflammatory cytokine synthesis. (+)-Naloxone crosses the placenta. (+)-Naloxone is used in the research of preterm birth[1].
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(+)-Naloxone | (+)-Naloxone is a TLR4 inhibitor and the dextrorotatory enantiomer of the non-opioid Naloxone (HY-17417A) that lacks opioid receptor binding activity. (+)-Naloxone binds to MD2, preventing LPS from binding to TLR4, thereby inhibiting TLR4 signaling, downstream NFκB activation, and proinflammatory cytokine synthesis. (+)-Naloxone crosses the placenta. (+)-Naloxone is used in the research of preterm birth. | |||||||||||||||||||||
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